Fibrinopeptide A (FPA)

Fibrinopeptides A and B are formed by the action of thrombin on fibrinogen; therefore, the presence of FPA indicates that thrombin has acted on fibrinogen.

The measurement is the most sensitive assay done to determine thrombin action. FPA reflects the amount of active intravascular blood clotting; this occurs in a subclinical DIC, which is common in patients with leukemia of various types and may be associated with tumor progression. FPA elevations can occur without intravascular thrombosis, decreasing the value of a positive test.

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